Zhu, Senlin

Senlin Zhu is a fourth-year Ph.D. student in Animal Nutrition at the College of Animal Sciences, Zhejiang University, and will be based at ETH Zurich until June 2025. His doctoral research focuses on the gastrointestinal microbiome of dairy cows and its interactions with the host, exploring novel antioxidant secondary metabolites through bioinformatics, deep learning techniques, and experimental validation. During his time at ETH, he will delve into the hydrogenase enzymes in the cow rumen using deep learning approaches, with the aim of applying these findings to methane reduction strategies.

Publications:

Zhu, S.-L., Gu, F.-F., Tang, Y.-F., Liu, X.-H., Jia, M.-H., Valencak, T.G., Liu, J.-X., and Sun, H.-Z. (2023). Dynamic fecal microenvironment properties enable predictions and understanding of peripartum blood oxidative status and non-esterified fatty acids in dairy cows. J. Dairy Sci., S0022030223006197. external page https://doi.org/10.3168/jds.2022-23066.

Jia, M., Zhu, S., Xue, M.-Y., Chen, H., Xu, J., Song, M., Tang, Y., Liu, X., Tao, Y., Zhang, T., et al. (2024). Single-cell transcriptomics across 2,534 microbial species reveals functional heterogeneity in the rumen microbiome. Nat Microbiol 9, 1884–1898. external page https://doi.org/10.1038/s41564-024-01723-9.

Gu, F., Zhu, S., Hou, J., Tang, Y., Liu, J.-X., Xu, Q., and Sun, H.-Z. (2023). The hindgut microbiome contributes to host oxidative stress in postpartum dairy cows by affecting glutathione synthesis process. Microbiome 11, 87. external page https://doi.org/10.1186/s40168-023-01535-9.

Gu, F., Zhu, S., Tang, Y., Liu, X., Jia, M., Malmuthuge, N., Valencak, T.G., McFadden, J.W., Liu, J.-X., and Sun, H.-Z. (2023). Gut microbiome is linked to functions of peripheral immune cells in transition cows during excessive lipolysis. Microbiome 11, 40. external page https://doi.org/10.1186/s40168-023-01492-3.

Wu, J.-J., Zhu, S., Tang, Y.-F., Gu, F., Liu, J.-X., and Sun, H.-Z. (2022). Microbiota-host crosstalk in the newborn and adult rumen at single-cell resolution. BMC Biol. 20, 280. external page https://doi.org/10.1186/s12915-022-01490-1.

Wu, J.-J., Zhu, S., Tang, Y.-F., Gu, F., Valencak, T.G., Liu, J.-X., and Sun, H.-Z. (2023). Age- and Microbiota-Dependent Cell Stemness Plasticity Revealed by Cattle Cell Landscape. Research 6, 0025. external page https://doi.org/10.34133/research.0025.

Xue, M.-Y., Wu, J.-J., Xie, Y.-Y., Zhu, S.-L., Zhong, Y.-F., Liu, J.-X., and Sun, H.-Z. (2022). Investigation of fiber utilization in the rumen of dairy cows based on metagenome-assembled genomes and single-cell RNA sequencing. Microbiome 10, 11. external page https://doi.org/10.1186/s40168-021-01211-w.